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April 6, 2005

Urine hyaluronidase RNA shows promise in detecting bladder carcinoma

Topics: Medical Science News

According to an April 1 report in Cancer(via Reuters), urine levels of hyaluronidase RNA detect bladder carcinoma with greater sensitivity and specificity than other markers(Cancer 2005;103:1356-1362). When researchers compared the sensitivity and specificity for diagnosis of bladder carcinoma using hyaluronidase RNA in cellular pellet from voided urine samples with those of CK-20 RNA, hyaluronic acid, and urine cytology, hyaluronidase mRNA was detected in 90.8% of patients with malignant bladder tumors, 10.2% of those with benign bladder pathology, and none of those in the control group. CK-20 (cytokeratin 20) mRNA was detected in 78.1% of malignant cases and 2.9% of benign cases. False positive cytologic results were returned in 30.9% of benign cases, and it also had a lower sensitivity (68.9%) than the other two tests.

The researchers note that these results translate into overall sensitivity and specificity in diagnosing bladder carcinoma of 90.8% and 93.4% for hyaluronidase mRNA; substantially higher than the 85.8% and 60.7% for a hyaluronic acid level above 58.5 unit/mg protein. This high sensitivity is among the best reported using a single test," the investigators write.

Related reading:
The simultaneous use of telomerase, cytokeratin 20 and CD4 for bladder cancer detection in urine.

Quantitative detection of cytokeratin 20 mRNA expression in bladder carcinoma by real-time reverse transcriptase-polymerase chain reaction.

cross posted at Hyscience

Posted by Richard at April 6, 2005 3:33 PM

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