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March 14, 2008

Study: 'New Anti-cancer Agent Can Overcome Resistance To Drugs'

Topics: Breast Cancer

Researchers report that a new anti-cancer agent called STX140 that targets breast cancer can overcome resistance to cancer drugs.

Tumors that are initially responsive to chemotherapy can develop resistance to it, allowing the cancer to progress. Studies have shown that one of the key reasons for the development of resistance is a protein pump called P-glycoprotein. Resistant cancer cells express P-glycoprotein and this removes anti-cancer drugs from the cell before they are able to kill the cell. STX140 works by stimulating a natural cell suicide process and is able to kill cancer cells which express the P-glycoprotein pump. Read more ...

Related reading: P-glycoprotein expression is a marker for chemotherapy resistance and prognosis in advanced ovarian cancer.

Posted by Richard at March 14, 2008 1:19 PM

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